Elanco Animal Health announced the approval of Imrestor™ (pegbovigrastim injection) – the first product of its kind for the dairy industry.

Available only by veterinary prescription, Imrestor is now FDA approved for the reduction in the incidence of clinical mastitis in the first 30 days of lactation in periparturient dairy cows and periparturient replacement dairy heifers. Imrestor is a protein that helps support the natural function of a dairy cow’s immune system during the critical time around calving, when she is most vulnerable to mastitis.

Pivotal efficacy studies conducted for FDA approval showed a 28 percent reduction in clinical mastitis incidence among cows and heifers that received Imrestor compared with control animals. Mastitis is the most common disease among dairy cows, affecting as many as 1 in 4 cows. Clinical mastitis affects each cow’s potential leading to reduced conception rates an increased risk for another case of mastitis and lost milk production potential throughout the lactation.

Immune suppression at calving can leave cows vulnerable to infection and an increased risk of mastitis.6  Dairy cows and heifers are in need of protection particularly at calving due to a decline in neutrophils – the primary type of white blood cell that recognizes and destroys harmful bacteria. Imrestor helps restore the function7* and increase the number1,7* of neutrophils at calving which helps the cow to fight invading bacteria that cause mastitis.

The launch of Imrestor is aligned with Elanco’s eight-point antibiotic stewardship plan that ensures the responsible use of antibiotics, reduces shared-class antibiotic use and replaces antibiotics with alternatives. The plan was outlined by Elanco President Jeff Simmons at a White House antibiotic stewardship forum last year.

Available in pre-filled, single-dose syringes, Imrestor is administered with two injections – one seven days prior to the anticipated date of calving** and the other within 24 hours after calving – thus helping to protect the cow against mastitis when she needs it most. Imrestor does not require a meat or milk withdrawal period. Imrestor will be available for purchase in 10, 50, and 100 dose pack sizes. The product availability date will be announced at a later time. Dairy producers are encouraged to contact their veterinarian to discuss incorporating Imrestor into their herd health program.